NAD+
A vital coenzyme researched for cellular energy and longevity.
Overview
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell. It is not a peptide, but it is one of the most popular compounds among peptide and longevity users. NAD+ is essential for energy metabolism, DNA repair, and the activity of sirtuins, the proteins linked to longevity. Levels decline with age, which has driven interest in NAD+ and its precursors.
Dosing
Injection
- Starting dose
- 250 mg
- Common dose
- 250–500 mg
- Frequency
- 1–4× weekly (protocol-dependent)
- Notes
- Given as a slow IV infusion in multi-session protocols.
Oral
- Starting dose
- 250 mg
- Common dose
- 250–500 mg
- Frequency
- 1× daily
- Notes
- Oral bioavailability is poor; precursors (NMN/NR) are often preferred.
Reported research/reference doses for educational purposes only. Always verify against primary literature and applicable regulations. Not medical advice.
How it works
NAD+ acts as a coenzyme in redox reactions that produce cellular energy (ATP). It is also a substrate for sirtuins, PARPs, and CD38, which regulate DNA repair, inflammation, and metabolism. Raising NAD+ levels is studied as a way to support cellular repair and healthy aging.
Common research uses
- Cellular energy and metabolism research
- DNA repair and sirtuin activation
- Longevity and healthy aging studies
- Supporting mitochondrial function
Considerations
Injectable NAD+ is popular in clinics, while oral precursors (NMN, NR) are more bioavailable for some uses. High doses can cause flushing or nausea. Research compound; quality varies by source.