NMN
A NAD+ precursor studied for energy, metabolism, and longevity.
Overview
NMN (nicotinamide mononucleotide) is a non-peptide compound and direct precursor to NAD+. It has become extremely popular in the longevity community as an oral way to raise NAD+ levels. Research suggests it may support energy metabolism, mitochondrial health, and age-related decline, though human data are still emerging.
Dosing
Oral
- Starting dose
- 250 mg
- Common dose
- 250–1000 mg
- Frequency
- 1× daily
- Notes
- Take in the morning; sublingual powder absorbs better.
Reported research/reference doses for educational purposes only. Always verify against primary literature and applicable regulations. Not medical advice.
How it works
NMN is converted to NAD+ inside cells through the salvage pathway. Higher NAD+ supports sirtuin activity, DNA repair enzymes (PARPs), and mitochondrial energy production, which together are thought to support metabolic and cellular health.
Common research uses
- Raising NAD+ levels
- Mitochondrial and metabolic health
- Longevity and anti-aging research
- Physical performance support
Considerations
Oral NMN is convenient and generally well tolerated, though optimal dosing is debated. Storage matters: keep away from heat and moisture. Quality control varies between suppliers.