Ipamorelin
A selective ghrelin-mimetic that gently stimulates growth hormone release.
Overview
Ipamorelin is a synthetic pentapeptide classified as a growth hormone secretagogue (GHS). It mimics the action of ghrelin to stimulate the release of growth hormone from the pituitary. It is favored for its relatively high selectivity for GH release with minimal impact on cortisol and prolactin compared to older GHRPs.
Dosing
Injection
- Starting dose
- 200 mcg
- Common dose
- 200–500 mcg
- Frequency
- 1–3× daily
- Notes
- Often dosed before bed or post-workout.
Reported research/reference doses for educational purposes only. Always verify against primary literature and applicable regulations. Not medical advice.
Amino acid sequence
Aib-His-D-2-Nal-D-Phe-Lys-NH2
How it works
Ipamorelin binds to the ghrelin/growth hormone secretagogue receptor (GHSR-1a) on pituitary cells, triggering a pulse of growth hormone release. Its selectivity reduces the unwanted stimulation of other hormones, yielding a cleaner GH profile.
Common research uses
- Growth hormone pulse research
- Muscle recovery and lean mass
- Bone density and metabolism studies
- Anti-aging research
Considerations
Research compound without established human safety data. Often cycled and paired with GHRH analogues like CJC-1295. Research use only.