MK-677
An oral growth hormone secretagogue that raises GH and IGF-1 over time.
Overview
MK-677 (Ibutamoren) is a non-peptide, orally active growth hormone secretagogue that mimics ghrelin. Unlike injectable GHRPs, it is taken by mouth and produces a sustained, long-term elevation of growth hormone and IGF-1. It does not cause a sharp pulse, instead gently raising baseline levels.
Dosing
Oral
- Starting dose
- 10 mg
- Common dose
- 10–25 mg
- Frequency
- 1× daily
- Notes
- Often taken before bed; monitor appetite and blood glucose.
Reported research/reference doses for educational purposes only. Always verify against primary literature and applicable regulations. Not medical advice.
How it works
MK-677 activates the ghrelin receptor (GHSR-1a), leading to increased growth hormone secretion over the day. Chronic use raises IGF-1 levels, supporting recovery, bone density, and lean mass. Its oral bioavailability makes it one of the most convenient GH secretagogues.
Common research uses
- Sustained GH and IGF-1 elevation
- Lean muscle and recovery
- Bone density research
- Sleep quality studies
Considerations
Can cause increased appetite, water retention, and transient insulin resistance. Liver enzyme monitoring is often recommended. Research compound.